Cannabidiol Gel Given Fragile X Youth in Trial Seen to Ease Anxiety, Other Behaviors

Zynerba‘s Zygel (ZYN002), a cannabidiol gel placed on the skin, was well-tolerated and led to a “clinically meaningful” easing of anxiety and other behavioral symptoms in children and teenagers with fragile X syndrome, according to results of a clinical trial in Australia.

The findings, “A phase 1/2, open-label assessment of the safety, tolerability, and efficacy of transdermal cannabidiol (ZYN002) for the treatment of pediatric fragile X syndrome,” were published in the Journal of Developmental Disorders.

Recent studies suggest that behavioral abnormalities in people with fragile X and other neurological conditions are linked to problems in the endocannabinoid system, which is thought to be modulated by cannabidiol (CBD) — a naturally occurring chemical found in cannabis that does not get users “high.”

Zygel is a CBD formulated clear gel that is manufactured pharmaceutically to deliver controlled amounts of CBD into

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