Cannabis use is associated with increased risk of developing major depression and suicidality among adolescents, according to research published in JAMA Psychiatry. Cannabis is the drug most commonly abused by adolescents worldwide, and researchers sought to evaluate the gravity of its effect on the development of major depression, anxiety, and suicidal behavior.
Longitudinal and prospective studies used data from 269 articles published on Medline, Embase, CINAHL, PsychInfo, and Proquest Dissertations and Theses to assess cannabis use in adolescents younger than 18 years and development of depression from 18 to 32 years. The odds ratio was adjusted for the presence of depression, anxiety, and/or suicidal behavior at baseline.
On the basis of the quantitative analysis, including data from 23,317 individuals, the odds ratio of developing depression for cannabis users in young adulthood compared with nonusers was 1.37. The odds ratio for suicidal behavior was 1.50, and 3.46 for suicidal attempt. The odds