Tetrahydrocannabinol (THC), the drug’s primary psychoactive ingredient, was found to effectively reduce intraocular pressure (IOP) in the short term, particularly amongst males. However, when used in conjunction with medical cannabis’ non-psychoactive component, cannabidiol (CBD), IOP increased on average by almost 20%.
Previous research has found THC has a short-term impact in lowering IOP, but the effects of CBD have been largely unknown.
The Indiana University (IU) study revealed male mice experienced a near 30% decrease in IOP eight hours after exposure to standalone TCH treatment. A 22% reduction was also observed after four hours.
However, the effect was weaker in female mice, which experienced a 17% decrease in IOP after four hours, while no difference was measured after eight hours.
IU researchers also analysed the impact medical cannabis containing both THC and CBD had on mice. They found CBD had a blocking affect on THC, preventing it from lowering IOP, and instead