A meta-study of cannabis research reveals that female mammals — including humans — are more likely to habitually consume cannabis, Science Daily reports.
The review of research published in the journal Frontiers looked at a wide range of animal and human studies regarding cannabis use and the mammalian endocannabinoid system and compared that to changes in hormones and hormone-driven body systems and associated behaviors.
It’s clear that risks and outcomes of cannabis use differ between biological sexes. Males appear more likely to try cannabis and use higher doses. Females appear more likely to go from trying cannabis to developing a regular habit of use.
Researchers theorize that this is due to a complicated web of hormone-system effects that differ between the sexes and are modulated by cannabinoids. While testosterone increases risk-taking behavior, estrogen seems to control social behavior and the filtering of sensory input. Cannabinoids change the levels of different